1.Basic Info.

Product Name: Fluocinolone acetonide
Synonyms:Fluocinolone acetate
CAS No: 67-73-2
MF: C26H32F2O7
MW:494.52Purity:99%
Package:1kg/aluminum cans
Appearance:white crystall powder.
USES: Used for allergic dermatitis, eczema, etc.

2.Product Description:

Fluocinonide for fluorine containing synthetic, potent steroids. External use can make the dermal capillary contraction, inhibition of epidermal cell proliferation or regeneration, inhibit fibroblast connective tissues in the newborn, stable intracellular lysosomal membrane, anti-inflammatory, antipruritic effect. Absorbed through intact skin after topical.

After absorption and system administration of corticosteroids in the body's metabolism, mainly in the liver metabolism, discharged by the kidneys. Fluocinonide is suitable for corticosteroid effective skin disease, such as eczema (especially infant eczema), neurodermatitis, skin pruritus, contact dermatitis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, solar dermatitis. But need to pay attention to long-term or large area use can cause skin atrophy, telangiectasia, the occurrence of acne like dermatitis, perioral dermatitis, folliculitis, increased susceptibility to infection etc.. I can cause allergic contact dermatitis.

Properties white or white crystalline powder, odorless, tasteless. [alpha]D20+80 - +88 degrees (two oxygen six ring). Soluble in acetone, slightly soluble in ethanol, two oxygen six ring, insoluble in water and petroleum ether.

It appears as white or white-like crystalline powder and is odorless and tasteless. [α] D20+80-+88° (dioxane). It is soluble in acetone, slightly soluble in ethanol, dioxane but insoluble in water and petroleum ether. It is obtained through the sulfonic esterfication, ring-opening reaction and further 16-steps reactions starting from the 11α-hydroxy-16α, 17α-epoxy pregnane-4-ene-3, 20-dione. It can be applied to atopic dermatitis, contact dermatitis, eczema and other skin diseases.

3.Product Applications:

Glucocorticoid; anti-inflammatory. It is suitable in the treatment of eczema, neurodermatitis, skin pruritus, contact dermatitis, psoriasis, dermatitis and other diseases.

Fluocinolone acetonide is a synthetic, fluorine-containing potent steroid. Topical administration of it can cause dermal capillary contraction and can inhibit epidermal cell proliferation or regeneration, inhibit the newborn of the fibroblast cells inside the connective tissue and stabilize the intracellular lysosomal membrane with anti-inflammatory and anti-itching effect. After topical administration, it can be absorbed through intact skin. After its absorption, similar as the metabolism of corticosteroid after systemic administration, it is mainly metabolized in the liver and can be excreted by the kidneys.

Fluocinolone acetonide is suitable for treating the skin disease to which corticosteroid is effective skin such as eczema (especially eczema), neurodermatitis, skin pruritus, contact dermatitis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, and solar dermatitis. However, it should be note that long-term or large-scale application can cause skin atrophy, telangiectasia and the occurrence of acne-like dermatitis, perioral dermatitis, folliculitis, and increased susceptibility to infection and so on. Allergic contact dermatitis can also occur in some cases.