17 Alpha Hydroxyprogesterone for Cancer Treatment 68-96-2

Basic info.

Product Name:17 Alpha Hydroxyprogesterone

Chemical name: 17-alpha-hydroxypregn-4-ene-3,20-dione

Molecular formula: C21H30O3

Molecular weight: 330.47

CAS NO.: 68-96-2

Appearance: White or almost white crystalline powder

Assay: ≥99.0%

Melting point: ≥214°C

Munufacturer:Kafen

Description:

The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. CAH is a group of inherited disorders caused by specific gene mutations and associated with cortisol-related enzyme deficiencies. About 90% of CAH cases are caused by a mutation in the 21-hydroxylase gene (also called P450c1 or CYP21A2) and may be detected due to the accumulation of 17-OHP in the blood. The 17-OHP test may be used to screen for CAH in older children or adults before symptoms appear or to confirm a CAH diagnosis in people with symptoms.

17-OHP testing may produce false-positive test results. If the level is elevated but not so high that it is diagnostic of CAH, other tests may be performed, such as androstenedione and testosterone. An ACTH stimulation test may be also be ordered as a follow-up test (in CAH, ACTH stimulation will markedly increase 17-OHP levels). Molecular genetic testing may be performed to detect CYP21A2 gene mutations thatcan cause the condition. A karyotype test may be ordered as a follow-up test to detect chromosome disorders and to help determine a baby's sex. Electrolytes may be ordered to measure the person's sodium and potassium levels.

Application:

The hormone 17-hydroxyprogesterone is a building block for producing the hormone cortisol. Cortisol is produced mainly by the adrenal cortex (the outer part of the two adrenal glands, located above the kidneys). Cortisol is called the "stress hormone" because it's secreted in larger amounts as part of the body's response to physical or emotional stress.In kids, the most common cause of cortisol deficiency, and consequently high levels of 17-hydroxyprogesterone, is one of the forms of the genetic disorder congenital adrenal hyperplasia (CAH).

17-hydroxyprogesterone is elevated in patients with congenital adrenal hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.