Product Name: Deslorelin Acetate
Sequence: Glp-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt
Cas No.: 57773-65-5
Molecular Formula: C64H83N17O12
Molecular Weight: 1282.47
Purity (HPLC): 99.0%min.
Appearance: White powder
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content (Karl Fischer): ≤8.0%
Acetate Content (HPIC): ≤12.0%
MS (ESI): Consistent
Mass Balance: 95.0~105.0%

Product Description:

Deslorelin acetate is releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (oestrogen).

Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

Deslorelin is a synthetic hormone that stimulates the release of the pituitary hormones in the mare that cause ovulation from mature ovarian follicles. It's use permits the mare to be bred at an optimal time for conception with a higher rate of pregnancy.It is manufactured as an implant that releases the drug continually for about 72 hours. It is also available in injectable form that allows between 16 to 21 hours of activity.

Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones.

One commercial form of Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. Another form is available in the USA, Sucromate Equine, which was FDA-approved for use in horses in November 2010.[3] This is manufactured by Thorne BioScience LLC and was introduced to the USA market following the withdrawal of Ovuplant. The Deslorelin products are currently approved for use in veterinary medicine and to promote ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion. Suprelorin is a slowly releasing deslorelin implant used for chemical castration of dogs and ferrets. It is marketed by Virbac. Deslorelin is also used to treat benign prostate hyperplasia in dogs.

Usage

Deslorelin is used to stimulate hormones which facilitate the breeding of mares at an optimal time, leading to a higher rate of successful pregnancy.Deslorelin is regularly used in non-pregnant broodmares for the management of their heat cycle.

Deslorelin is being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It belongs to the family of drugs called gonadotropin-releasing hormone analogs. It is used for the induction of ovulation in mares. Deslorelin binds to and activates pituitary gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production.

Applications:

Deslorelin was successfully trialed in the US and was approved for veterinary use under certain circumstances. In Europe, it was approved for use in equine assisted reproduction.

It is also being trialed in humans to study its efficacy in treatment of breast cancer in women , and in treating precocious puberty and congenital adrenal hyperplasia in male and female children.

Precautions

Because deslorelin may prolong the inter-estrous interval for some mares that do not get pregnant on that cycle, some veterinarians remove the implant after ovulation in order to decrease the chance of this happening.

Deslorelin is FDA approved for use in horses and is a prescription drug. U. S. federal law restricts the use of the drug by or on the lawful written or oral order of a licensed veterinarian.

Commonly, no use for deslorelin exists with competition horses. It would be forbidden in any drug-free competition. Check with the proper regulatory group.

Function:

(1) Deslorelin acetate is an injectable gonadotropin-releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and estrogen).
(2) One commercial form of Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant...Another form is available in the USA, Surrogate Equine.
(3) The Deslorelin products are currently approved for use in veterinary medicine and to promote ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock.
(4) Deslorelin is primarily used for the initial flare effect upon the pituitary and its associated surge of LH secretion.
(5) Deslorelin is also being trialed in humans to study its efficacy in the treatment of breast cancer in women and in treating precocious puberty and congenital adrenal hyperplasia in male and female children.

Specifications