Pharmaceutical Dexamethasone Palmitate  CAS: 14899-36-6 Treat  Ophthalmic Diseases

Basic Views: 

Alias: Dexamethasone Palmitate

Model NO.: 14899-36-6

Customized: Non-Customized

Suitable for: Adult

Purity: >99%

Trademark:CQSP

Delivery: TNT, UPS, DHL, EMS, FedEx

Discount: More Quantity, More Discount

Specification: 10grams

HS Code: 3004409061

Certification: ISO 9001, Kosher,USP,BP

Appearance: White or Light Yellow Crystalline Powder

Transport Package: 1kg/Aluminium Foil Bag or as Required

Usage: Anti-Inflammatory and Anti-Allergic Effects

Payment: T/T, Western Union, Money Gram and Bitcoin

FOB Price:$1/g

MOQ:10g

Origin:China

Production Capacity:5000kg/month

Delivery time: Parcel can be sent out within 24hours after your payment, 4~7 days to arrive.

Product description:

Abstract

PURPOSE:

Dexamethasone palmitate (DXP) is a lipophilic prodrug of dexamethasone (DXM), a potent corticosteroide used to treat a variety of ophthalmic diseases. The aim of the study was to characterize the sustained release capacity (in rabbit), efficacy (in rat and rabbit), and safety (in rabbit, cat, and minipig) of intravitreal (IVT) DXP emulsions in preclinical models.

METHODS:

Oil-in-water emulsions of DXP were administered by IVT injections in rats, rabbits, cats, or minipigs. Efficacy was assessed in rabbits by the inhibition of VEGF-induced vascular leakage and in rats by inhibition of laser-induced choroidal neovascularization. Concentrations of DXP and DXM in aqueous humor, vitreous, retina, choroid, and blood were determined to characterize the ocular and systemic pharmacokinetic (PK) profile. Complete ophthalmic examinations (indirect ophthalmoscopy, slit-lamp biomacroscopy, electroretinography, tonometry) were performed to assess the ocular safety of IVT DXP doses up to 2,600 μg in minipig, followed by histopathologic examinations. A validated feline model of DXM-induced elevated intraocular pressure (IOP) was used to assess the ocular hypertensive impact (i.e., the safety) of an IVT injection of DXP emulsion.

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